KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
43.64
Human Site:
T686
Identified Species:
60
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
T686
K
K
M
T
E
I
Q
T
P
E
N
T
P
R
L
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
T686
K
K
M
T
E
I
Q
T
P
E
N
T
P
R
L
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
T685
K
K
M
T
K
I
Q
T
P
E
N
T
P
R
L
Dog
Lupus familis
XP_535848
1288
147094
T686
N
K
M
T
K
I
Q
T
P
E
N
T
P
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
T684
K
K
M
S
K
I
Q
T
P
E
N
T
P
R
L
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
A640
H
Q
R
H
K
T
V
A
L
D
G
T
L
F
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
T525
I
E
Q
S
G
T
M
T
G
G
G
S
K
I
M
Chicken
Gallus gallus
NP_989849
1274
145838
T657
K
N
L
Q
K
I
P
T
P
E
N
A
P
R
L
Frog
Xenopus laevis
P50532
1290
146971
T680
K
G
L
N
K
I
Q
T
P
E
N
I
P
R
L
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
T685
Q
S
M
G
S
I
S
T
P
E
N
I
P
R
L
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
T682
K
N
T
A
P
I
H
T
P
E
E
S
P
R
L
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
Y954
L
E
K
V
N
K
E
Y
A
E
S
R
A
E
A
Honey Bee
Apis mellifera
XP_396862
1282
148175
T623
R
C
K
Q
K
I
Q
T
P
E
N
V
P
R
L
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
T693
R
D
L
A
P
N
P
T
N
P
L
P
A
P
R
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
D685
S
K
I
L
N
F
S
D
P
D
N
V
P
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
T629
K
L
K
E
K
V
K
T
P
E
D
V
P
R
L
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
T757
F
N
L
Q
P
I
S
T
P
E
N
V
P
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
6.6
N.A.
6.6
60
66.6
60
53.3
6.6
60
6.6
40
P-Site Similarity:
100
100
100
93.3
N.A.
100
26.6
N.A.
33.3
73.3
80
66.6
60
26.6
73.3
20
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
0
0
0
6
6
0
0
6
12
0
6
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
0
0
0
0
0
6
0
12
6
0
0
0
0
% D
% Glu:
0
12
0
6
12
0
6
0
0
77
6
0
0
6
0
% E
% Phe:
6
0
0
0
0
6
0
0
0
0
0
0
0
6
0
% F
% Gly:
0
6
0
6
6
0
0
0
6
6
12
0
0
0
0
% G
% His:
6
0
0
6
0
0
6
0
0
0
0
0
0
0
0
% H
% Ile:
6
0
6
0
0
65
0
0
0
0
0
12
0
6
0
% I
% Lys:
48
36
18
0
48
6
6
0
0
0
0
0
6
0
0
% K
% Leu:
6
6
24
6
0
0
0
0
6
0
6
0
6
0
77
% L
% Met:
0
0
36
0
0
0
6
0
0
0
0
0
0
0
6
% M
% Asn:
6
18
0
6
12
6
0
0
6
0
65
0
0
0
0
% N
% Pro:
0
0
0
0
18
0
12
0
77
6
0
6
77
6
0
% P
% Gln:
6
6
6
18
0
0
42
0
0
0
0
0
0
0
6
% Q
% Arg:
12
0
6
0
0
0
0
0
0
0
0
6
0
77
6
% R
% Ser:
6
6
0
12
6
0
18
0
0
0
6
12
0
0
0
% S
% Thr:
0
0
6
24
0
12
0
83
0
0
0
36
0
0
0
% T
% Val:
0
0
0
6
0
6
6
0
0
0
0
24
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _